. Author manuscript; available in PMC: 2021 Jun 1.

Published in final edited form as: AIDS Behav. 2020 Jun;24(6):1653–1662. doi: 10.1007/s10461-019-02684-5

Table IV.

Estimates of the natural direct, natural indirect and total effect of the association between ACEs and allostatic load mediated through alcohol use or smoking.^a

Outcome measure	Mediator	Natural direct effect Beta (95% CI^b)	P	Natural indirect effect Beta (95% CI)	P	Total effect Beta (95% CI)	P
AL highest risk quartile
	Alcohol use	0.37 (−0.04, 0.77)	0.07	0.01 (−0.03, 0.06)	0.59	0.38 (−0.03, 0.80)	0.06
	Smoking	0.48 (0.08, 0.89)^c	0.02	−0.02 (−0.08, 0.04)	0.50	0.46 (0.05, 0.87) ^c	0.03
AL highest risk quartile with bidirectional cortisol
	Alcohol use	0.42 (0.01, 0.84) ^c	0.05	0.01 (−0.03, 0.06)	0.54	0.44 (0.02, 0.85) ^c	0.04
	Smoking	0.54 (0.13, 0.95) ^c	0.01	−0.02 (−0.08, 0.04)	0.50	0.52 (0.10, 0.94) ^c	0.01

Models adjusted for race, sex, educational attainment, age, and HIV medication adherence

CI confidence interval

Statistically significant, p < 0.05