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. Author manuscript; available in PMC: 2021 Feb 1.
Published in final edited form as: Curr Opin Biotechnol. 2019 Nov 27;61:82–88. doi: 10.1016/j.copbio.2019.11.004

Table 1 –

Recent developments in plant-made cancer biologics. CPMV: cowpea mosaic virus; ΔXF: with plant xylose/fucose deleted glycans; Fc: crystallizable fragment of human antibody; HPV: human papillomavirus; JgCSMV: Johnson grass chlorotic stripe mosaic virus; mAb: monoclonal antibody; PAP: prostatic acid phosphatase; PVX: potato virus X; RCNMV: red clover necrotic mosaic virus; TAA: tumor-associated antigen; TMV: tobacco mosaic virus; TRAIL: tumor necrosis factor-related apoptosis-inducing ligand

Protein Application Produced in Reference
CPMV particles Immunotherapy, drug delivery Vigna unguiculata (viral propagation) or N. benthamiana (transient expression) [16–21]
TMV particles Immunotherapy, drug delivery, imaging N. benthamiana (propagation or transient expression) [16,33–36,40]
PVX particles Immunotherapy, drug delivery N. benthamiana (viral propagation) [17,22,38]
PeMV particles Immunotherapy N. benthamiana (viral propagation) [40]
TMV-Albumin particles Immunotherapy, drug delivery N. benthamiana (viral propagation), [32]
RCNMV particles Drug delivery - [41]
TMV-coated mesoporous silica nanoparticles Drug delivery N. benthamiana (viral propagation) [37]
TRAIL-coated PVX Drug delivery, therapeutic N.benthamiana (viral propagation) [39]
JgCSMV particles Drug delivery, therapeutic Sorghum halepense (viral propagation) [42,43]
PAP-IgM Fc Immunotherapy Nicotiana tabacum (transgenic, in vitro cultured) [6]
GA733–2-Fc-KDEL Immunotherapy N. benthamiana (transient expression) [7]
Oligomannose rituximab Immunotherapy N. benthamiana (transient expression) [27]
Ofatumumab Immunotherapy N. benthamiana (transient expression) [26]
Trastuzumab Immunotherapy N. benthamiana (transient expression) [24]
CO17-1A-KDEL Immunotherapy N. benthamiana (transient expression) [25]
Anti-CD20 scFv-Fc-hIL2 immunocytokine (ΔXF) Therapeutic N. benthamiana (transient expression) [30]
Anti-HER2 scFv-Fc Therapeutic Arabidopsis thaliana [28]
Viscumin (mistletoe lectin) Therapeutic N. benthamiana (transient expression) [52]
Avaren-Fc Therapeutic N. benthamiana (transient expression) [59]
CTB-KDEL Immunotherapy N. benthamiana (transient expression) [53]
LALF32-51-E7 HPV vaccine Therapeutic vaccine N. benthamiana (transient expression) [13,14]
CCL21 Immunotherapy Solanum lycopersicum (transient expression) [23]