Table 1. Sepsis definitions used for cohort evaluation.

Sepsis definitions
Sepsis positive	• Met the IPSO definition of severe sepsis • Treated as sepsis by the care team (documentation of concern for sepsis following a multidisciplinary bedside huddle OR use of the sepsis algorithm/order set AND at least 48 hours of IV antibiotics)
IPSO severe sepsis	• Blood culture • Two fluid boluses • Antibiotic administration
IPSO severe sepsis plus manual chart review	• IPSO definition • Manual chart review with:  – Diagnosis of sepsis or septic shock OR  – High clinical suspicion resulting in use of the sepsis algorithm or order set

Abbreviations: IPSO, improving pediatric sepsis outcomes; IV, intravenous.