Table 2. Test characteristics of the interruptive sepsis alert based on cohort definitions.
| Patients with sepsis ( n = 424) | Patients with IPSO severe sepsis ( n = 76) | Patients with IPSO severe sepsis confirmed by chart review ( n = 60) | |
|---|---|---|---|
| Sensitivity in % (95% CI) | 92.5 (89.5–94.8) | 57.9 (46.0–69.1) | 73.3 (60.3–83.9) |
| Specificity in % (95% CI) | 95.6 (95.2–96.0) | 92.5 (92.0–93.0) | 92.5 (92.0–93.0) |
| Positive predictive value in % (95% CI) | 46.0 (43.7–48.3) | 5.2 (4.3–6.3) | 5.2 (4.4–6.0) |
| Negative predictive value in % (95% CI) | 99.7 (99.6–99.8) | 99.7 (99.6–99.8) | 99.8 (99.8–99.9) |
| Positive likelihood ratio (95% CI) | 20.9 (19.0–22.9) | 7.7 (6.3–9.4) | 9.8 (8.3–11.5) |
| Negative likelihood ratio (95% CI) | 0.08 (0.06–0.11) | 0.5 (0.4–0.6) | 0.3 (0.2–0.4) |
| Number needed to screen | 2 | 19 | 19 |
Abbreviations: CI, confidence interval; IPSO, improving pediatric sepsis outcomes.