Figure 2.
Structure of collagen XVII. The intracellular domain (lCD; aa 1–456), transmembrane domain (TD; aa 457–489), and extracellular domain (ECD; aa 490–1497). The ECD includ es the NC16A domain (aa 490–562). The ICD lies in the outer plaque of the HD and the ECD spans the lamina Iucida, extends to the lamina densa, and loops back into the lamina Iucida.