Table 1.
Collagen XVII as it pertains to cancer development.
| Cancer | Protein | mRNA | References |
|---|---|---|---|
| Squamous cell carcinoma | + | + | (51–53) |
| Actinic keratosis | + | (51, 52) | |
| Melanoma | + | (55) | |
| Basal cell carcinoma | +/– | + | (9) |
| Pancreatic carcinoma | * | (14) | |
| Thyroid cancer | + | (66) | |
| Colorectal cancer | ↑ | ↑ | (67, 68) |
| Lung cancer | ↑ | ↑ | (69, 70) |
| Nasopharyngeal cancer | ↓ | (71) | |
| Salivary gland cancer | – | – | (72) |
| Cervical cancer | ↑ | (7, 73) | |
| Breast cancer | ↓ | (7, 74) |
+, expression; –, absence; ↑, upregulation; ↓, downregulation; *The 120 kD shed ectodomain is the predominant protein form detected.