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. 2020 Jan 6;139(4):735–771. doi: 10.1007/s00401-019-02122-9

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Characteristics of neuronal and astroglial phospho-tau deposits in the frontal cortex in GGT linked to MAPT P301T mutation; a–i: case 1; j–o: cases 3 and 4. In case 1, phospho-tau deposits, as revealed with the AT8 antibody, are finely granular in the cytoplasm, or form perinuclear halos, or globular tangles (long white arrow) (a, b, d, g). In cases 3 and 4, phospho-tau deposits are granular (long white arrow), globular, or round Pick-like bodies (short white arrow) (j, k). Astrocytic deposits in case 1 are typical GAIs with perikaryal globular structures or forming dense perinuclear inclusions of variable size consistent with immature stages (short black arrow) (d–f); together with astrocytes with longer cell and fine processes (long black arrow) (h), and astrocytic plaque-like structures (asterisk) (i). Astrocytic deposits in cases 3 and 4 show a predominance in astrocytes with longer cell processes (white arrows) (l, m, o) in addition to typical GAIs (short black arrows). Paraffin sections processed for AT8 immunohistochemistry and slightly counterstained with haematoxylin; bar = 25 μm