Fig. 3.

YKL40 is lightly expressed in very small subpopulations of astrocytes in the cerebral cortex in controls (Contr), but the number of YKL40-positive astrocytes, and the intensity of the immunoreactions per cell, are largely increased in cortical astrocytes in GGT linked to MAPT P301T mutation (a, b). AQ4 is also markedly increased in the cerebral cortex in GGT compared with controls (c, d). In contrast, the expression of the glutamate transporter GLT1 is reduced in the different regions of the cerebral cortex in GGT when compared with controls (e–h). The glucose transporter CLUC-t is expressed in the vessel wall of capillaries, and diffusely so in the neuropil in the cerebral cortex in control brains. The number of GLUC-t-immunoreactive capillaries is largely increased in the cerebral cortex in GGT linked to MAPT P301T mutation. This is accompanied by focal sprouting of capillaries in the cerebral cortex (thin arrow) and focal disruption of capillaries (thick arrow) in the frontal cortex and white matter in GGT (i–l). FC frontal cortex, TC temporal cortex, WM white matter. Case 1; paraffin sections processed for immunohistochemistry slightly counterstained with haematoxylin; a–h, k–l, bar = 45 μm; i, j bar = 100 μm