Table 4.
Summary of studies of exposure to antiepileptics (AEDs) and risk of pneumonia included in review
| Study, year, country and data source | Study type | Participants (sample size) | Age (years) | Accommodation | Confounders adjusted for | Population | Drugs investigated | Exposure definition | Comparison group | Outcome or case definition | Risk of pneumonia |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Taipale et al. [23] 2019, Finland, nationwide registers | Cohort | New AED users (n = 5769), non-users (n = 5769) | Mean age 80 | Community-dwelling | Adjusted for covariates | AD | AEDs | AED initiation after AD diagnosis | Non-users | Hospitalization or death due to pneumonia | aHR 1.92, 95% CI 1.63–2.26 |
AD Alzheimer’s disease, AED antiepileptic drugs, aHR adjusted hazard ratio, CI confidence interval