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. 2020 Mar 25;10:5467. doi: 10.1038/s41598-020-62352-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Mitochondrial membrane potential analysis in T. cruzi trypomastigotes treated with compounds 1d, 1e, 3b and 4a for two hours labeled with JC-1 probe (0.2 μM). The fluorescence was measured in a flow cytometer (ATTUNE). Minimum (untreated – negative control, C−) and maximum (treated with CCCP- 100 µg/mL - positive control, C+) alterations in the mitochondrial membrane potential were obtained. Fluorescence was quantified by calculating the ratio between the channels BL2/BL1. One representative experiment of two assays is shown.