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. 2020 Mar 25;10:5424. doi: 10.1038/s41598-020-62255-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Study design. CD2F1 male mice were exposed to LD90 total body irradiation (TBI). Post-TBI, mice were euthanized at five time points: 6 h (marked as d0), one day (d1), three days (d3), seven days (d7) and nine days (d9). Two control cohorts (C1 and C7) accounted for the baseline. Whole genome miRNA profiling, global metabolomics and targeted metabolomics were conducted at each time point.