Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Mar 25;10:5424. doi: 10.1038/s41598-020-62255-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

The non-canonical network linked to hematopoiesis. This network was generated around the two hub proteins FLT-3LG and EPO. Both of these proteins were upregulated during the Early phase post-TBI. FLT-3LG was significantly (p < 0.001) elevated from baseline. EPO was not significantly elevated during the Early phase, but its expression gradually increased to meet the significance level at d7 post-TBI. In this network, these proteins are marked by triangular nodes. The miRNAs enriching hematopoiesis networks are marked by the oval-shaped nodes. Furthermore, we identified five significantly enrihed (p < 0.05) sub-networks under the overarching hematopoiesis network, namely development of hematopoietic progenitor cells, differentiation of erythroid cells, differentiation of erythroid precursor cells, bone marrow cancer and leukemia. The nodes representing these biological functions and dieases are rectangular in shapes. The arrow-headed and blunt-headed edges represent activating and associative relationship between two nodes, respectively. All of the protein and miRNA nodes are colored based on their regulation levels observed during the Early phase post-TBI, and the color code is at right bottom. The rectangular nodes of the subnetworks representing the biological functions and diseases remained uncolored.