Table 1.
List of top 5 highly upregulated and downregulated microRNAs during Early phase post-TBI.
| miRNA | Log2(Fold Change) | Relevance to present objective |
|---|---|---|
| miR-714 | 5.19 | Significantly upregulated in rodent thymic lymphoma cells at six months post-TBI74 |
| miR-3971 | 5.02 | Stimulates cellular production |
| miR-150-5p | 4.80 | Cross-species validated radiation marker for time- and dose-dependent reduction in expression in plasma8. We found subsequent reduction in expressions in the Mid (−1.31) and Late phases (−1.53). |
| miR-5120 | 4.76 | Decreased in hematopoietic progenitor cells exposed to pollutants, like benzene75 |
| miR-5104 | 4.63 | Another candidate to be decreased in hematopoietic progenitor cells exposed to pollutants, like benzene75 |
| miR-204-5p | −5.24 | Reduced serum load, an established oncogenic marker76 |
| miR-96-5p | −6.14 | Oncogenic marker and apoptosis regulator77 |
| miR-124-3p | −6.25 | Decreased load promotes cancer78 |
| miR-9-5p | −6.57 | Reduced expression as marker of bone-related cancer79 |
| miR-211-5p | −7.21 | Overexpressed miR-211-5p and miR-204-5p promote resistance against melanoma80 |