. 2020 Mar 25;10:5424. doi: 10.1038/s41598-020-62255-w

Table 2.

List of top 5 highly upregulated and downregulated metabolites during Early phase post-TBI.

Metabolite	Log₂(Fold Change)	Relevance to present objective
Diacylglycerol	0.79	Linked to fatty acid synthesis in cancer cells⁸¹ and insulin resistance⁸²
Hydrocortisone	0.79	Higher hydrocortisone correlates with and regulates cardiac function⁸³
Phosphatidylcholine	0.55	A marker of oxidative stress⁸⁴
Cholesteryl oleate	0.53	Linked to cardiac dysfunction⁸⁵
Triacylglycerol (isomer 6)	0.52	A monopalmitic acid triglyceride
Phosphatidylethanolamine	−0.60	Along with phosphatidylcholine, phosphatidylethanolamine plays a significant role in mitochondrial function, activities several enzymes
Stearylamine	−0.65	Immuno-modulator⁸⁶
Phosphatidylcholine	−0.67	Along with phosphatidylethanolamine, phosphatidylcholine plays significant role in mitochondrial function
Docosapentaenoic acid	−0.79	An omega-3 fatty acid with multiple health benefits
Triamterene	−0.98	Controls nephrotoxicity
Allyl sulfide	−1.62	Facilitates anticancer activities⁸⁷