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. 2020 Mar 25;3:144. doi: 10.1038/s42003-020-0870-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a The expression of alkaline phosphatase in calvarial cells that were isolated from the E15 wild-type (+/+) and homozygous (Cp/Cp) embryos and then cultured for 16 days in the differentiation medium. Bar, 1 mm. The expression patterns of OPN and RUNX2 in the zeugopods of the E15 embryos and COL10 and OPN in the digits. Magenta arrowheads indicate the faint expression of each gene. Bar, 500 μm. b The expression of IHH, PTCH2, PTHrP, COL2, and COL10 as shown by in situ hybridization, with the neighboring sections of the zeugopod in the hindlimbs of the E6 wild-type (+/+), heterozygous (Cp/+), and homozygous (Cp/Cp) embryos from the JB strain. Ant, anterior; Pos, posterior; Dis, distal; Pro, proximal. Bar, 100 μm.