Table 3.

Multivariate Fine–Gray model (Model 7) (N = 14,781)^a parameter estimates based on Fine–Gray model.

Covariate	Level	Parameter estimate	SE	SHR	95% CI	p
Age at diagnosis	<40	0.45410	0.057	1.58	1.41–1.76	<0.0001
	40–69			REF
	≥70	−0.18590	0.084	0.83	0.70–0.98	0.0268
Anatomic stage	I			REF
	IIA	0.79969	0.058	2.23	1.99–2.49	<0.0001
	IIB	1.23600	0.064	3.44	3.04–3.90	<0.0001
	IIIAB	1.42681	0.077	4.17	3.58–4.84	<0.0001
	IIIC	1.85219	0.096	6.37	5.28–7.70	<0.0001
Biologic subtype	TNBC	0.62773	0.056	1.87	1.68–2.09	<0.0001
	HR+/HER2+(T)(T)	−0.38992	0.125	0.68	0.53–0.87	0.002
	HR−/HER2+(T)	0.06342	0.124	1.07	0.84–1.36	0.61
	HR+/HER2−			REF
Gradeb	1			REF
	2	0.56614	0.119	1.76	1.40–2.22	<0.0001
	3	1.19932	0.121	3.32	2.62–4.21	<0.0001

SHR refers to the subdistribution hazard ratio of mortality with breast cancer.

SHR subdistribution hazard ratio, CI confidence interval, Ref reference group (1.00).

^aPatients with complete data including age, stage, hormone receptor (HR) status (HR+: ER+ or PR+ and HR−: ER− and PR−), HER2 status, and grade were included.

^bHistologic grade or nuclear grade (if histologic grade is not available); HG (n = 4724); NG (n = 10,057).