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. 2020 Mar 25;10:5442. doi: 10.1038/s41598-020-62403-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Association between ECM classification by IR score and grade with disease free survival. ECM3 grade III (ECM3 GIII, solid black line), non-ECM3 grade III (non-ECM3 GIII, dotted black line), ECM3 grade I-II (ECM3 GI-II, solid grey line) and non-ECM3 grade I-II (non-ECM3 GI-II, dotted grey line). p-value calculated by Log-rank test.