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. 2020 Mar 25;10:5442. doi: 10.1038/s41598-020-62403-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Collagen characteristics of ECM3 and non-ECM3 areas. Representative images of Masson’s trichrome staining in tumors classified as ECM3 (top panels) and non-ECM3 (bottom panels). In the small boxes, images of the collagen classifier at pixel level are shown. Red pixels: ECM3; blue pixels: non-ECM3.