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. 2020 Mar 25;10:5447. doi: 10.1038/s41598-020-61799-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Volume of white matter regions in the DS group relative to the volume of the same regions in the TD group. Following registration into the DT template, Ln-J mean values for the DS and TD groups were computed for most of the regions described in the JHU white matter atlas (Oishi et al. 2008) plus additional regions (noted with a ⁺ sign) relevant for the current investigation. Then the difference in Ln-J for the two groups was calculated (DS Ln-J mean – TD Ln-J mean). These difference values were ranked from most negative (DS smaller volume than TD) to positive (DS larger volume than TD) and are color-coded by the pathway type. Error bars represent the standard deviation of the Ln-J for the DS group. On the X-axis, we report the Ln-J difference as well as the average volume for the DS group expressed as percentage of the average volume of the TD group. In addition, we note with an asterisk regions in which t-tests comparing that ROI’s volume between groups were statistically significant (p < 0.05) following Bonferroni correction for multiple comparisons.