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. 2020 Mar 19;7:31. doi: 10.3389/fcvm.2020.00031

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Copyright © 2020 Diallo, Benmoussa, Laugier, Osman, Hitzler and Provost.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MicroRNA profile of PRT-treated human platelets. Clinical PCs were either left untreated in donor plasma (Control group) or treated with PRT agents Mirasol or Intercept, or with the Additive solution, used as the vehicle control for Intercept. Platelets were isolated from the clinical PCs, and total RNA was extracted and pooled from six donors per group prior to small RNA-Seq analysis. (A) Heatmap representation of the platelet microRNA profiles with clustering analysis, where fold changes vs. control PCs are indicated in graded color intensity. (B) Circular diagram representing the 20 most abundant microRNAs in each pooled sample, along with other microRNAs and their relative proportion. PCs, platelet concentrates; PRT, pathogen reduction technologies.