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. 2020 Mar 19;11:306. doi: 10.3389/fphar.2020.00306

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Copyright © 2020 Cao, Tian, Li, Lv, Han, Zhuang, Cheng, Gong, Ying, Jin and Gao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The knockout of NLRP3 mimicked the effects of EPO on the NLRP3 inflammasome in ALI. EPO (5 U/g) was injected into the peritoneal cavity of mice after LPS (15 mg/kg) stimulation of NLRP3 knockout (KO) mice and wild-type (WT) mice, and the mice were sacrificed 8 h later. The lung tissues were harvested to measure the protein expression levels of pro-caspase-1, pro-IL-1β, cleaved caspase-1, and NLRP3 (A–E) by Western blotting. The data are presented as the mean ± SD. The differences among groups were assessed by two-way ANOVA and the post hoc test (Turkey method) was applied to investigate the differences one by one. n = 7 per group.