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. 2020 Mar 19;11:227. doi: 10.3389/fphys.2020.00227

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Copyright © 2020 Nieman, Al-Khalisy, Kollisch-Singule, Satalin, Blair, Trikha, Andrews, Madden, Gatto and Habashi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A systematic review of data from trauma patients who were ventilated with either conventional mechanical ventilation (CMV) or the time-controlled adaptive ventilation (TCAV) method using the airway pressure release ventilation (APRV) mode. Boxplots are mean and standard error for (A) Injury Severity Score (ISS), (B) percentage of patients who developed ARDS (ARDS%), and (C) in-hospital mortality (%) from 16 published papers using standard of care CMV. Black circles indicate the results in each category using the TCAV method at the R Adam Cowley Shock Trauma Center in Maryland. Although patients in the TCAV group were in the high-ISS range, they had the lowest levels of both ARDS incidence (ARDS%) and in-hospital mortality (%) as compared with patients ventilated using CMV (Andrews et al., 2013). Permissions obtained from Wolters Kluwer Health, Inc. License 4699420119915.