Table 1.

Top ten predicted essential genes not found in OGEE or DEG database.

Ranking	Gene	Function	Number of references		P-value*
			Viable	Lethal
1	RpL13	Structural constituent of ribosome	0	0	–
2	pnr	Transcription factor; activator of proneural achaete-scute complex genes	11	37	<0.001
3	Prosα4	Proteasome α4 subunit	7	0	<0.001
4	RpS2	Ribosomal protein S2	2	16	<0.001
5	Hsc70-3	Heat shock 70-kDa protein cognate 3	4	32	<0.001
6	RpS11	Ribosomal protein S11	2	2	NS
7	ct	Homeoprotein that functions as a transcriptional factor	24	230	<0.001
8	CG4374	Transcription factor	0	1	NS
9	lilli	Transcription factor	7	32	<0.001
10	N	Notch signaling pathway core component	30	314	<0.001

^*Significance of enrichment (Fisher’s exact test) of references describing the gene as lethal compared to the number of references describing the gene as viable.