Figure 2.

Interplay between EMT-TFs and pyrimidine metabolism genes. As the normal cells undergo oncogenic transformation, oncogenes activate and upregulate PyM genes. PyM in cancer is essential for proliferation, but the catabolic activity of PyM enzymes is further required to maintain aggressive cells in a mesenchymal-like state. This review aims to open a discussion that could lead to identification of possible feedback loops that connect the PyM back to EMT. The question marks in the figure indicate possibility of an existing feedback activation.