. 2018 May 29;15(9):555–567. doi: 10.1038/s41575-018-0020-y

Table 1.

Mediators of immune cell recruitment across LSECs

Adhesion factor	Ligand	Function
ICAM1	αLβ2 integrin	Firm adhesion of CD4 cells and CD8 cells, transmigration of T_reg cells and B cells
VCAM1	α4β1 integrin	Capture and firm adhesion of T cells and B cells
VAP1	Unknown	Adhesion and transmigration of lymphocytes and monocytes
Stabilin 1	Unknown	Transmigration of CD4 T cells, predominantly T_reg cells
Stabilin 2	αMβ2 integrin	Adhesion of lymphocytes
MADCAM1	α4β7 integrin	Adhesion of α4β7 integrin-positive subset of T cells
Hyaluronan	CD44	Adhesion of neutrophils during liver injury promotes platelet adhesion, which in turn enables intrasinusoidal CD8⁺ T cell docking
CD151	Forms microdomains to support VCAM1	Firm adhesion of lymphocytes via a VCAM1-mediated pathway
CXCL9–CXCL11	CXCR3	Transendothelial migration of T cells
CXCL16	CXCR6	Mediates T cell recruitment and natural killer T cell sinusoidal surveillance
CX₃CL1	CX₃CR1	Adhesion and transmigration of monocytes

CX₃CL1, CX₃C-chemokine ligand 1; CX₃CR1, CX₃C-chemokine receptor 1; CXCL, CXC-chemokine ligand; CXCR, CXC-chemokine receptor; ICAM1, intercellular adhesion molecule 1; LSEC, liver sinusoidal endothelial cell; MADCAM1, mucosal addressin cell adhesion molecule 1; T_reg cell, regulatory T cell; VAP1, vascular adhesion protein 1; VCAM1, vascular cell adhesion molecule 1.