Table 1.
Association of DCSIGN1-336 in three independent cohorts from Thailand
| Genotype distribution | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Number | Frequency (%) | Cases versus controls a | DHF versus DF a | |||||||
| Cohort and group | GG | GA | AA | GG | GA | AA | OR | P b | OR (95% c.i.) | P b |
| RA cohort | ||||||||||
| Control | 5 | 51 | 240 | 1.7 | 17.2 | 81.1 | ||||
| DEN | 4 | 39 | 190 | 1.5 | 17.3 | 81.2 | 0.970 | 0.98 | ||
| DF | 0 | 1 | 50 | 0.0 | 2.0 | 98.0 | 0.090 | 0.0012 | 14.31 (3.34–61.23) | 2.3 × 10−4 |
| DHF | 4 | 38 | 140 | 2.2 | 20.9 | 76.9 | 1.286 | 0.33 | ||
| SI cohort | ||||||||||
| Control | 1 | 44 | 169 | 0.5 | 20.6 | 79.0 | ||||
| DEN | 0 | 49 | 190 | 0.0 | 20.5 | 79.5 | 0.968 | 0.98 | ||
| DF | 0 | 6 | 66 | 0.0 | 8.3 | 91.7 | 0.344 | 0.018 | 3.79 (1.62–8.87) | 0.0024 |
| DHF | 0 | 43 | 124 | 0.0 | 25.7 | 74.3 | 1.302 | 0.34 | ||
| KK cohort | ||||||||||
| Control | 3 | 31 | 149 | 1.6 | 16.9 | 81.4 | ||||
| DEN | 0 | 16 | 114 | 0.0 | 12.3 | 87.7 | 0.616 | 0.18 | ||
| DF | 0 | 0 | 27 | 0.0 | 0.0 | 100.0 | 0.008 | 0.012 | 99.75 (12.70–783.54) | 0.037 |
| DHF | 0 | 16 | 87 | 0.0 | 15.5 | 84.5 | 0.807 | 0.63 | ||
The SI and KK cohorts were replication cohorts. c.i., confidence interval; DEN, all individuals with dengue disease; DF, dengue fever; DHF, dengue hemorrhagic fever.
a The combined group of homozygotes with respect to the rare allele and heterozygotes was compared with the group of homozygotes with respect to the frequent allele.
bTwo-sided exact Fisher test.