Table 2.

Association of DCSIGN1-336 in the three independent cohorts combined

			Genotype distribution
Polymorphism			Number			Frequency (%)			Cases versus controls a		DHF versus DF a
Code	Name	Group	11	12	22	11	12	22	OR	P b	OR (95% c.i.)	P b
4	DCSIGN1-336	Control	9	126	558	1.3	18.2	80.5
		DEN	4	104	494	0.7	17.3	82.3	0.904	0.52
		DF	0	7	143	0.0	4.7	95.3	0.204	2.0 × 10−6	5.84 (2.77–12.31)	1.4 × 10−7
		DHF	4	97	351	0.9	21.5	77.3	1.189	0.27
5	DCSIGN1-139	Control	62	310	322	8.9	44.7	46.4
		DEN	55	244	306	9.1	40.3	50.6	0.846	0.15
		DF	12	57	83	7.9	37.5	54.6	0.720	0.08	1.24 (0.86–1.79)	1.0
		DHF	43	187	223	9.5	41.3	49.2	0.893	0.38
7	DCSIGN1.in2+11	Control	7	101	585	1.0	14.6	84.4
		DEN	1	77	524	0.2	12.8	87.0	0.806	0.20
		DF	0	6	146	0.0	3.9	96.1	0.224	4.5 × 10−5	4.60 (2.07–10.22)	5.4 × 10−5
		DHF	1	71	378	0.2	15.8	84.0	1.032	0.91
12	DCSIGN1.ex4SF	Control	688	4	0	99.4	0.6	0.0
		DEN	594	9	0	98.5	1.5	0.0	2.588	0.17
		DF	151	1	0	99.3	0.7	0.0	1.181	1.0	2.61 (0.56–12.23)	0.59
		DHF	443	8	0	98.2	1.8	0.0	3.087	0.10
13	DCSIGN1.ex4RPT	Control	0	8	685	0.0	1.2	98.8
		DEN	1	7	595	0.2	1.2	98.7	1.151	0.97
		DF	1	3	148	0.7	2.0	97.4	2.328	0.31	0.33 (0.09–1.16)	0.23
		DHF	0	4	447	0.0	0.9	99.1	0.771	0.91
15	DCSIGN1.in5-178	Control	6	96	586	0.9	14.0	85.2
		DEN	1	74	521	0.2	12.4	87.4	0.827	0.28
		DF	0	5	144	0.0	3.4	96.6	0.201	4.0 × 10−5	5.30 (2.25–12.46)	3.0 × 10−5
		DHF	1	69	377	0.2	15.4	84.3	1.067	0.76
16	DCSIGN1.ex6TI	Control	0	7	679	0.0	1.0	99.0
		DEN	0	6	589	0.0	1.0	99.0	0.989	1.0
		DF	0	1	148	0.0	0.7	99.3	0.683	1.0	1.61 (0.32–8.08)	1.0
		DHF	0	5	441	0.0	1.1	98.9	1.103	1.0
17	DCSIGN1.in6-37	Control	6	74	598	0.9	10.9	88.2
		DEN	1	57	544	0.2	9.5	90.4	0.797	0.25
		DF	0	7	142	0.0	4.7	95.3	0.371	0.01	2.56 (1.19–5.52)	0.02
		DHF	1	50	402	0.2	11.0	88.7	0.949	0.86
26	DCSIGN1.2281	Control	287	330	72	41.7	47.9	10.4
		DEN	227	283	94	37.6	46.9	15.6	1.186	0.15
		DF	49	78	25	32.2	51.3	16.4	1.500	0.04	0.73 (0.50–1.08)	0.14
		DHF	178	205	69	39.4	45.4	15.3	1.099	0.48
36	DCSIGN1.3197	Control	11	138	510	1.7	20.9	77.4
		DEN	8	113	459	1.4	19.5	79.1	0.902	0.50
		DF	3	21	125	2.0	14.1	83.9	0.658	0.10	1.51 (0.93–2.45)	0.12
		DHF	5	92	334	1.2	21.3	77.5	0.994	1.0
37	DCSIGN1.3852	Control	353	258	47	53.6	39.2	7.1
		DEN	285	173	33	58.0	35.2	6.7	0.837	0.15
		DF	71	51	5	55.9	40.2	3.9	0.913	0.64	0.89 (0.59–1.33)	0.64
		DHF	214	122	28	58.8	33.5	7.7	0.811	0.13

c.i., confidence interval; DEN, all individuals with dengue disease; DF, dengue fever; DHF, dengue hemorrhagic fever.

^a The combined group of homozygotes with respect to the rare allele and heterozygotes was compared with the group of homozygotes with respect to the frequent allele.

^bTwo-sided exact Fisher test.