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. 2005 Oct 16;12(11):980–986. doi: 10.1038/nsmb999

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© Nature Publishing Group 2005

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(a) The interaction sites between nsp7 and nsp8I/II. Green, nsp7; blue, nsp8. (b) T1 and T2 heterotetramer formation. The two dimers from one tetramer are illustrated by the surface representation and ribbon diagram, respectively. Residues: green, polar; yellow, hydrophobic; red, acidic; blue, basic. Ribbons: green, nsp7; blue, nsp8I; orange, nsp8II. (c) Possible pathway for assembly of the complex by heterotetramers T1 and T2. (d) Hexadecameric supercomplex construction with 'bricks' of nsp8 and 'mortar' of nsp7. The angle between nsp8I and nsp8II is labeled in magenta. In c and d, nsp7 molecules interacting with nsp8I and nsp8II are colored yellow-green and blue-green, respectively.