Skip to main content
. 2015 Jul 21;16(8):802–809. doi: 10.1038/ni.3212

Figure 2. Signaling pathway of type I and type III IFNs.

Figure 2

Type I IFNs signal via a heterodimeric receptor composed of the high-affinity chain IFNAR2 and the low-affinity chain IFNAR1. Type III IFNs also signal via a heterodimeric receptor, but it is composed of two different chains: the IFN-λR1 high-affinity chain and IL-10R2 low-affinity chain (which is shared with other cytokines). Both high-affinity chains interact with JAK1, whereas the two low-affinity chains interact with TYK2. Signaling downstream of both receptors results in the assembly of the ISGF3 transcription factor, which coordinates the expression of genes containing an interferon response element (ISRE).