Table 1.

Mutations in the receptor-binding motif of SARS-CoV

Strain	Host	Year	Truncation in receptor-binding motif	Residue 442	Residue 472	Residue 479	Residue 480	Residue 487
hTor02	Human	2002–2003	No	Tyr	Leu	Asn	Asp	Thr
cSz02	Civet	2002–2003	No	Tyr	Leu	Lys	Asp	Ser
hcGd03	Human and civet	2003–2004	No	Tyr	Pro	Asn	Gly	Ser
cHb05	Civet	2005	No	Tyr	Pro	Arg	Gly	Ser
hHae08	Human	2008	No	Phe	Phe	Asn	Asp	Ser
hOptimize	Human	In vitro design	No	Phe	Phe	Asn	Asp	Ser
cOptimize	Civet	In vitro design	No	Tyr	Pro	Arg	Gly	Thr
bHKU3	Bat	2005	Yes	Ser	Gly	Ser	Thr	Val
bWIV1	Bat	2013	No	Ser	Phe	Asn	Asp	Asn
bRsSHC014	Bat	2013	No	Trp	Pro	Arg	Pro	Ala

Data from Hu et al. 2012 (ref.⁸³). SARS-CoV, severe acute respiratory syndrome coronavirus.