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. 2009 Jul 24;8(8):661–677. doi: 10.1038/nrd2852

Figure 2. Ligands of dendritic cell-specific ICAM3-grabbing non-integrin 1 (DC-SIGN).

Figure 2

DC-SIGN co-crystallized with the natural epitopes Galβ(1-4)[Fucα(1-3)]GlcNAcβ(1-3)Gal (Protein Data Bank code 1SL5) (a) and Manα(1-6)[Manα(1-3)]Manα(1-6)Man (PDB code 1SL4) (b). The protein backbone is depicted in ribbon style, carbohydrates are shown in ball and stick style and the grey sphere is Ca2+. Part c shows the structures of DC-SIGN antagonists. The glycomimetics compound 1 (Ref. 69) and compound 2 (Ref. 72) have only a slightly improved affinity compared with the natural ligands Manα(1-2)Man68 and Lewisx (Ref. 72), whereas the non-carbohydrate antagonists compound 3 and compound 4 have half-maximal inhibitory concentration (IC50) values in the low micromolar range73.