Table 2.
Immune correlates as a basis to optimize vaccine strategies
| Vaccine | EliSA IgG titre* | ||
|---|---|---|---|
| Prime | Boost | Mouse | Macaque |
| DNA | rAd | 200,000 | 75,000 |
| rAd | rAd | 100,000 | Not determined |
| rAd | None | 16,000 | Not determined |
| DNA | DNA | 12,000 | Not determined |
| DNA | None | 6,400 | 2,000 |
| *End point antibody titres were measured in sera from mice immunized with different combinations of DNA and recombinant adenovirus (rAd) vectors encoding Ebola virus proteins, and used to prioritize candidate vaccines for testing in cynomolgus macaques. ELISA, enzyme-linked immunosorbent assay; Ig, immunoglobulin. | |||