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. 2020 Mar 27;12(3):84–98. doi: 10.4254/wjh.v12.i3.84

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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Effect of arachidonic acid: docosahexaenoic acid ratios on mechanistic mediators of lipid metabolism. A-E: VL17-A cells were treated with different ratios of arachidonic acid: docosahexaenoic acid for 24 h. Following this, the expression of several proteins that modulate lipid metabolism were examined, namely, SCD1 (A), PPAR-α (B), SREBP1c (C), CB1 (D) and CB2 (E). ^aP ≤ 0.05 and ^bP ≤ 0.01 compared to control; ^cP < 0.05 and ^dP < 0.01 compared to 1:1 ratio; ^eP < 0.05 compared to 4:1 ratio. Data is presented as mean ± SE (n = 3-4). AA: Arachidonic acid; DHA: Docosahexaenoic acid.