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. 2020 Mar 27;12(3):84–98. doi: 10.4254/wjh.v12.i3.84

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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Effect of arachidonic acid: docosahexaenoic acid ratios on mitochondrial respiratory functions. VL17-A cells were treated with different ratios of arachidonic acid: docosahexaenoic acid for 24 h and various parameters that determine the mitochondrial respiratory functions were examined. A: Elevation in AA:DHA ratios caused a gradual and significant decrease in basal respiration when compared to control. Similar results were observed when compared to treatment with 1:1 ratio, whereby basal respiration significantly reduced with 15:1 and 25:1 ratios; B: Maximal respiration decreased gradually with 1:1, 4:1, 15:1 and 25:1 ratios (by 35%, 44%, 54%, and 56%, respectively); C: Spare respiratory capacity showed a similar pattern of significant reductions (by 52%, 56%, 67%, and 68% over the increasing AA/DHA ratios; D: ATP production significantly reduced with elevation in AA:DHA 1:1, 4:1, 15:1, 25:1 ratios (by 25%, 33%, 44% and 41%, respectively); E: Proton leak decreased significantly with high omega ratio of 15:1 compared to control, and with 25:1 by 50% and 31%, when compared to control and 1:1 ratio, respectively. ^aP < 0.05 and ^bP < 0.01 compared to control; ^cP < 0.05 and ^dP < 0.01 compared to 1:1 ratio. Data is presented as mean ± SE (n = 4-5). AA: Arachidonic acid; DHA: Docosahexaenoic acid.