Figure 2. Basic pathogenesis of measles-virus infection.

Panels summarize features of the basic pathogenesis of measles-virus infection. a | Panel shows the spread of the virus through the body from the initial site of infection in respiratory epithelia to the skin, in which the diagnostic rash is formed. Sites of infection are overlaid with virus titre (pfu). b | Illustrates the appearance of clinical symptoms over time, including the diagnostic Koplik's spots and rash. c | Panel summarizes immune responses over time, including both B- and T-cell responses. Clinical symptoms arise coincident with the onset of the immune response. Pfu; plaque-forming unit. Modified with permission from Ref. 87 © (2001) Lippincott Williams & Wilkins.