Table 2.

RNAi-based clinical trials for respiratory syncytial virus

Phase	Subjects	Administration	Dosage regime	siRNA amount	Reference
I	Healthy males	Nasal spray	Single dose	1.5, 5, 15, 50, or 150 mg	[41]
			Single dose	5, 25, or 150 mg
			Daily dose for 5 days	5, 25, or 50 mg
II	Experimentally infected adults	Nasal spray	Daily dose for 5 days	75 or 150 mg	[42]
IIa	RSV-infected lung transplant patients	Aerosolized	Daily dose for 3 days	0.6 mg/kg/day	[43]