Newman 1979.

Methods	Double blind randomised clinical trial Randomisation: subjects randomly allocated on discharge from hospital after 2 week stabilisation on 60mg methadone to detoxification or continued maintenance.
Participants	Geographic region: Hong Kong Study setting: Hospital and outpatient clinic n = 100 males mean age = 38 years Eligibility criteria: male, 22‐58 years, history of heroin dependence for at least 4 years and at least one previous treatment, current heroin dependence by three consecutive positive urine samples, voluntary application for admission (criminal justice referrals excluded), resident with fixed address, absence of past or present major psychiatric or medical illness.
Interventions	Treatment: methadone maintenance ‐ flexible dose (average 97 mg / day). Control: detoxification from 60mg methadone at 1mg/day for 60 days, placebo thereafter.
Outcomes	Illicit drug use / Urinalysis (daily collection, analysed 2 x week for morphine only) Retention Criminal activity Mortality
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Adequate sequence generation?	Unclear risk	'Randomly assigned'
Allocation concealment?	Low risk	A ‐ Adequate 'neither patients nor clinic staff knew which group' 'pharmacist only staff aware'.
Incomplete outcome data addressed? All outcomes	Low risk	No missing data. Report ITT.
Free of other bias?	Low risk	No difference between group at baseline