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. 2019 Jun 3;4(7):1075–1087. doi: 10.1038/s41564-019-0465-y

Fig. 2. Mechanisms of DVG generation.

Fig. 2

a, Variations in the viral RdRp fidelity due to mutations or effects of virus-encoded co-factors, such as the influenza A virus (IAV) NEP or the paramyxovirus C protein, can favour the generation of DVGs. b, Variants of the nucleoprotein with altered binding to viral RNA can promote DVG generation. c, Variants of structural proteins, such as the PPXY domain in the matrix protein of arenaviruses, can lead to DVG generation. d, Inter- and intra-recombination events using homologous sequences (red) can lead to the formation of deletion DVGs.