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Predictive vs. achieved for the lungs–CTV V20Gy for single- (2a) and multi-institutional (2b) plans using the PC optimization objectives. Dotted lines reflect the 95% confidence intervals determined from the single institution validation. The intersection of the 95% confidence interval at an achieved V20Gy of 37% was used to determine a threshold predictive value, set at 31.3%. Any predictions higher than 31.3% automatically trigger the LS optimization objectives.
