Figure 2.

Transcription profiling of GPP neutrophils confirms the presence of a IFN-I signature. (a) Identification of genes that are differentially expressed in GPP. Horizontal and vertical lines represent significance and fold change thresholds, respectively. (b) Transcriptional modules enriched among the genes that are upregulated in GPP. The FDR for each module is reported, with the underlying upregulated genes shown as gray cells. (c) Enriched pathways detected among the genes that are upregulated in GPP. IFN-related pathways are highlighted in bold (d) Upstream regulator analysis showing that IRF7 and STAT1 drive the upregulation of numerous genes that are over-expressed in GPP. (e) Elevated IFN score in the neutrophils of patients with GPP, compared with controls. The data are presented as mean ± SD; *P < 0.05 (unpaired t test). FDR, false discovery rate; GPP, generalized pustular psoriasis; PRR, pattern recognition receptors; SD, standard deviation.