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. 2020 Apr;140(4):816–826.e3. doi: 10.1016/j.jid.2019.08.444

Figure 3.

Figure 3

Validation of the IFN-I signature in extended datasets. (a) Elevated IFN score in the neutrophils of patients with GPP and PV compared with healthy individuals. CAPS cases were analyzed as negative controls. The data are presented as mean ± SD; **P < 0.01 and ***P < 0.001 (1-way analysis of variance followed by Dunnett’s posttest). (b) Left: systemic flares are more prevalent in patients with GPP with high IFN scores (n = 8) compared with those with low IFN scores (n = 9). Right: PsA) is more prevalent in patients with PV with high IFN scores (n = 6) compared with those with low IFN scores (n = 11). In both groups, the cut-off between high and low scores was defined as the median +2SD of the values observed in healthy controls. *P < 0.05 (Fisher exact test). CAPS, cryopyrin associated periodic syndrome; GPP, generalized pustular psoriasis; PsA, psoriatic arthritis; PV, psoriasis vulgaris; SD, standard deviation.