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. 2020 Mar 12;16(9):1616–1628. doi: 10.7150/ijbs.40896

Figure 7.

Figure 7

Monitoring of liver metastasis development by noninvasive 3D fluorescence and photoacoustic imaging with Angiostamp800 and ICG. Fluorescence and photoacoustic imaging were performed 1 hour after ICG intravenous injection or 24 hours after Angiostamp800 intravenous injection. A) Projections from 3D fluorescence imaging of the liver with Angiostamp800. B) 3D bimodal fluorescence/microCT imaging of the liver with Angiostamp800. C) Liver sections from 3D ultrasound and photoacoustic (800 nm) imaging with Angiostamp800. The dotted white line represents the ROI used for photoacoustic signal quantifications. D) Fluorescence and E) photoacoustic signals measured from the liver with Angiostamp800. F) Projections from 3D fluorescence imaging of the liver with ICG. G) 3D bimodal fluorescence/microCT imaging of the liver with ICG. H) Liver sections from 3D ultrasound and photoacoustic (800 nm) imaging with ICG. I) Fluorescence and J) photoacoustic signals measured from the liver with ICG. n= 3 mice (healthy group), n= 6 mice per group (Early and Advanced); statistical analyses: one-way ANOVA tests were used (*p-value<0.05; **p-value<0.01; ***p-value<0.001; ****p-value<0.0001).