Figure 2.

Functions of the genes with methylation. The functions of the genes with methylation (marked with red) mainly focus on several aspects: DNA damaged, metabolic regulation, apoptosis, G protein-coupled signal transmission, cell division, and some plasma protein release. RUNX2 has an influence on DNA damage(marked with blue); THY1, ST8SIA6, MT1M, MT1G, and RGS10 participate in the metabolism process (marked with green); VIM has a connection with apoptosis (marked with yellow); TGR5(GPBAR1) is a G-protein-coupled bile acid receptor for bile acid mediating; SEPT9 plays a critical role of cytokinesis and INK4A (CDKN2A) is a cell cycle inhibitor(marked with light red); FBLIN1 is related to plasma glycoprotein generation(marked with orange).