Table 2.
Univariate and multivariate Cox proportional hazards analysis of progression-free survival.
| Varies | Univariate | Multivariate | |||||
|---|---|---|---|---|---|---|---|
| HR | 95%CI | P | HR | 95%CI | P | ||
| Age | 1.015 | (1.002- 1.029) | 0.025 | 1.007 | (0.992- 1.022) | 0.345 | |
| BMI | 1.064 | (1.010- 1.120) | 0.019 | 0.970 | (0.911- 1.032) | 0.337 | |
| FIGO (Ⅲ-Ⅳ vs. Ⅰ-Ⅱ) |
7.987 | (5.078- 12.564) | <0.001 | 6.609 | (4.013- 10.88) | <0.001 | |
| Histological subtype (serous vs. others) |
1.908 | (1.298- 2.806) | 0.001 | 1.272 | (0.843- 1.920) | 0.252 | |
| Histological grade (G2-G3 vs. G1) |
3.891 | (2.346- 6.454) | <0.001 | 1.943 | (1.126- 3.353) | 0.017 | |
| Optimal debulking (yes vs. no) |
1.550 | (1.097- 2.190) | 0.013 | 1.953 | (1.335- 2.856) | 0.001 | |
| Malignant ascites (yes vs. no) |
2.191 | (1.542- 3.113) | <0.001 | 1.184 | (0.816- 1.718) | 0.374 | |
| Lymph node metastases (yes vs. no) | 2.499 | (1.735- 3.600) | <0.001 | 1.832 | (1.167- 2.876) | 0.008 | |
| LMR (>3.8 vs. ≤3.8 ) |
0.401 | (0.271- 0.593) | <0.001 | 0.494 | (0.329- 0.742) | 0.001 | |
| CA125(U/ml) (≤34 vs.>34) |
1.719 | (1.127- 2.622) | 0.012 | 1.641 | (1.057- 2.550) | 0.027 | |
The multivariate Cox regression model demonstrated that LMR≤3.8 (HR = 0.494, 95% CI: 0.329-0.742, P = 0.001), and CA125>34 U/ml (HR = 1.641, 95% CI: 1.057-2.550, P = 0.027) were significantly associated with poor PFS. BMI, body mass index; FIGO, Federation of Gynecologists and Obstetricians; LMR, lymphocyte/monocyte ratio; CA125: cancer antigen 125.