Table 1. Solubility of Azilsartan as a Function of Temperature in Different Solvents under 0.1 MPaa.
solvent | T/K | xA | xAcalc | 100δ |
---|---|---|---|---|
methanol | 293.15 | 0.4074 | 0.3963 | 2.73 |
303.15 | 0.4761 | 0.4871 | –2.32 | |
313.15 | 0.5655 | 0.5739 | –1.48 | |
323.15 | 0.6575 | 0.6523 | 0.79 | |
333.15 | 0.7251 | 0.7203 | 0.66 | |
ethanol | 293.15 | 0.3771 | 0.3721 | 1.34 |
303.15 | 0.465 | 0.4644 | 0.12 | |
313.15 | 0.552 | 0.5540 | –0.37 | |
323.15 | 0.6153 | 0.6360 | –3.37 | |
333.15 | 0.7268 | 0.7076 | 2.65 | |
acetonitrile | 293.15 | 0.0493 | 0.05345 | –8.43 |
303.15 | 0.0709 | 0.0760 | –7.21 | |
313.15 | 0.0997 | 0.1050 | –5.34 | |
323.15 | 0.135 | 0.1412 | –4.59 | |
333.15 | 0.1764 | 0.1849 | –4.81 | |
n-propanol | 293.15 | 0.1285 | 0.1135 | 11.67 |
303.15 | 0.167 | 0.1757 | –5.21 | |
313.15 | 0.2629 | 0.2559 | 2.64 | |
323.15 | 0.3268 | 0.3506 | –7.30 | |
333.15 | 0.4683 | 0.4527 | 3.32 | |
isopropanol | 293.15 | 0.0998 | 0.0858 | 13.99 |
303.15 | 0.1394 | 0.1351 | 3.10 | |
313.15 | 0.1862 | 0.2011 | –8.03 | |
323.15 | 0.2755 | 0.2831 | –2.77 | |
333.15 | 0.3868 | 0.3768 | 2.58 | |
tetrahydrofuran | 293.15 | 0.4706 | 0.4644 | 1.32 |
303.15 | 0.5395 | 0.5390 | 0.10 | |
313.15 | 0.5956 | 0.6084 | –2.15 | |
323.15 | 0.6658 | 0.6711 | –0.79 | |
333.15 | 0.7390 | 0.7262 | 1.73 | |
methanol/water (8/2, v/v) | 293.15 | 0.1454 | 0.1537 | –5.69 |
303.15 | 0.2056 | 0.2075 | –0.93 | |
313.15 | 0.2819 | 0.2701 | 4.18 | |
323.15 | 0.3444 | 0.3395 | 1.41 | |
333.15 | 0.4047 | 0.4130 | –2.06 | |
ethanol/water (8/2, v/v) | 293.15 | 0.3022 | 0.2912 | 3.62 |
303.15 | 0.3729 | 0.3836 | –2.88 | |
313.15 | 0.4728 | 0.4793 | –1.38 | |
323.15 | 0.5772 | 0.5714 | 1.01 | |
333.15 | 0.6568 | 0.6547 | 0.32 | |
ethanol/water (5/5, v/v) | 293.15 | 0.0315 | 0.0273 | 13.28 |
303.15 | 0.0586 | 0.0478 | 18.37 | |
313.15 | 0.0801 | 0.0797 | 0.43 | |
323.15 | 0.1072 | 0.1264 | –17.94 | |
333.15 | 0.1999 | 0.1902 | 4.86 |
Standard uncertainties u are u(T) = 0.1 K, u(p) = 0.05 MPa, and related standard uncertainty ur(x) = 0.05 (0.95 level of confidence).