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. 2020 Mar 13;5(11):6141–6145. doi: 10.1021/acsomega.0c00156

Table 1. Solubility of Azilsartan as a Function of Temperature in Different Solvents under 0.1 MPaa.

solvent T/K xA xAcalc 100δ
methanol 293.15 0.4074 0.3963 2.73
  303.15 0.4761 0.4871 –2.32
  313.15 0.5655 0.5739 –1.48
  323.15 0.6575 0.6523 0.79
  333.15 0.7251 0.7203 0.66
ethanol 293.15 0.3771 0.3721 1.34
  303.15 0.465 0.4644 0.12
  313.15 0.552 0.5540 –0.37
  323.15 0.6153 0.6360 –3.37
  333.15 0.7268 0.7076 2.65
acetonitrile 293.15 0.0493 0.05345 –8.43
  303.15 0.0709 0.0760 –7.21
  313.15 0.0997 0.1050 –5.34
  323.15 0.135 0.1412 –4.59
  333.15 0.1764 0.1849 –4.81
n-propanol 293.15 0.1285 0.1135 11.67
  303.15 0.167 0.1757 –5.21
  313.15 0.2629 0.2559 2.64
  323.15 0.3268 0.3506 –7.30
  333.15 0.4683 0.4527 3.32
isopropanol 293.15 0.0998 0.0858 13.99
  303.15 0.1394 0.1351 3.10
  313.15 0.1862 0.2011 –8.03
  323.15 0.2755 0.2831 –2.77
  333.15 0.3868 0.3768 2.58
tetrahydrofuran 293.15 0.4706 0.4644 1.32
  303.15 0.5395 0.5390 0.10
  313.15 0.5956 0.6084 –2.15
  323.15 0.6658 0.6711 –0.79
  333.15 0.7390 0.7262 1.73
methanol/water (8/2, v/v) 293.15 0.1454 0.1537 –5.69
  303.15 0.2056 0.2075 –0.93
  313.15 0.2819 0.2701 4.18
  323.15 0.3444 0.3395 1.41
  333.15 0.4047 0.4130 –2.06
ethanol/water (8/2, v/v) 293.15 0.3022 0.2912 3.62
  303.15 0.3729 0.3836 –2.88
  313.15 0.4728 0.4793 –1.38
  323.15 0.5772 0.5714 1.01
  333.15 0.6568 0.6547 0.32
ethanol/water (5/5, v/v) 293.15 0.0315 0.0273 13.28
  303.15 0.0586 0.0478 18.37
  313.15 0.0801 0.0797 0.43
  323.15 0.1072 0.1264 –17.94
  333.15 0.1999 0.1902 4.86
a

Standard uncertainties u are u(T) = 0.1 K, u(p) = 0.05 MPa, and related standard uncertainty ur(x) = 0.05 (0.95 level of confidence).