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Schematic diagram of PBPK models in (A) healthy and (B) tumor-bearing mice intravenously administered with AuNPs and various inorganic and organic nanomaterials (INMs and ONMs), respectively. Except plasma and brain, each compartment is divided into three major parts: capillary blood, tissue interstitium, and endocytic/phagocytic cells (PCs) or tumor cells (TCs).
