Table 1. Summary of Tumor Delivery Efficiency Estimates for Different Types of Nanomaterials^*.

^*DE_Tlast, DE₂₄, and DE₁₆₈ represent tumor delivery efficiency estimated at the last sampling time point according to the original pharmacokinetic study at 24 h and 168 h, respectively. DE_max is the maximum tumor delivery efficiency based on individual PBPK simulation.

^aDE_{Tlast_PK} is the tumor delivery efficiency estimated at the last sampling time point according to the original pharmacokinetic study using the noncompartmental linear trapezoidal integration method as used by Wilhelm et al., i.e., area-under-the-tumor-concentration-curve (AUC) method.¹⁴

^bMedian (mean).