Table 3. Summary^* of the Differences and Major Findings between Current Study and the Previous Study by Wilhelm et al.(14).

^*DE_{Tlast_PK} is the tumor delivery efficiency estimated at the last sampling time point according to the original pharmacokinetic study using the noncompartmental AUC approach as used by Wilhelm et al.¹⁴ DE₂₄, DE₁₆₈, and DE_Tlast represent tumor delivery efficiency estimated at 24 h, 168 h, and the last sampling time point, respectively, according to the original pharmacokinetic study. DE_max is the maximum tumor delivery efficiency based on the individual PBPK simulation.

^aThe mean value of 1.48%ID was calculated from 193 included data sets based on the reported tumor delivery efficiencies by Wilhelm et al.¹⁴ and the Cancer Nanomedicine Repository (CNR) database. There were 238 data sets in the CNR database at the time of the present study, 232 of which were analyzed and reported in the Wilhelm et al.¹⁴ paper. One additional study containing 6 data sets was uploaded into the CNR database after the publication of the Wilhelm et al.¹⁴ paper. After excluding studies due to lack of information and/or did not meet the criteria for subsequent PBPK modeling and simulation as described in Figure 1, there were 193 data sets from the CNR database being included and analyzed.