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. 2020 Mar 26;21:80. doi: 10.1186/s13059-020-01997-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — CIRCOS plot [20] displaying (from outside to inside) chromosome numbers, chromosome ideograms, scatterplot complete with gene labels representing the osteoclast eQTL associations presented in Table 1 and Additional file 1: Table S2 (red), scatterplot representing the eBMD GWAS results (green) and gene ontology (GO) biological process groupings relevant to osteoclast biology. Osteoclast eQTL and eBMD GWAS associations are displayed as −log₁₀P values ranging from 0.01 > P > 1.0 × 10⁻¹⁵ (osteoclast eQTL) and 0.001 > P > 1.0 × 10⁻⁵⁰ (eBMD GWAS). GO biological process groupings displayed include membrane organisation (blue), regulation of cell migration (red), regulation of catalytic activity (purple), cation transport (orange) and I-kappaB kinase/NF-kappaB signalling (green)