Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Mar 26;8:39. doi: 10.1186/s40478-020-00914-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 3 — Stages of LP and AD-type pathology in donors grouped according to clinical diagnoses (a-d) and pathological diagnoses (e-h). a. Clinically-defined PD donors showed higher Braak α-synuclein stages than donors with atypical parkinsonian disorders. b. Thal amyloid-β phases were not different between clinical diagnostic groups. c. Braak NFT stage and d. CERAD neuritic plaque score were similar between PD, PSP and MSA donors, but higher in donors with other diagnoses. e-h. LP with an amygdala-predominant distribution or at least Braak stage 3 was present in 18% of donors with PSP tau pathology, in 25% of donors with GCI pathology and in 17% of donors with other types of neuropathology. f. In donors with LP, Thal amyloid-β phases were higher than in donors with GCI pathology or other pathological lesions, when controlling for age at death. g,h. Braak NFT stages (g) and CERAD neuritic plaques scores (h) were not different between donors with different pathological diagnoses. LP = Lewy pathology; PSP tau = tau pathology typical for progressive supranuclear palsy; GCI = glial cytoplasmic inclusion